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The invention relates to a process for the preparation of pharmaceutical preparations based on cis-platinum II -diamine dichloride using an aqueous-alcoholic carrier. The process of the invention allows the preparation of sterile and stable freeze-dried forms of cis-platinum II diamine dichloride containing mg of active ingredient, which forms can be prepared on an industrial scale and dissolved readily and rapidly, is used in a more advantageous and rational way in anti-tu-mother chemotherapy in comparison with the frozen forms of cis-platinum II -diamine chloride currently marketed.
These properties are obtained as a result of special precautions in the composition concentration of the solution to be freeze-dried, introduction of alcohols, adjustment of the pH of the solution to an appropriate value and as a result of the use of a preparation technique which as a final step includes freeze-drying of cis-platinum II diamine dichloride in aqueous-alcoholic medium.
The method of preparation, and especially the freeze-drying process, has been found to be economically advantageous and has enabled the very significant problems associated with freezing-drying cis-platinum II -diamine chloride in aqueous medium breakage of containers, very low yields to be solved. The inorganic platinum complexes constitute a very large class of substances possessing anti-tumor activity.
The antibiotic effect of such complexes was first discovered in by Rosenberg et al. Rosenberg et al. Attention was focused on the ability of these compounds to block the proliferation of certain test tumors in laboratory animals. It was also observed that cis-platinum II diamine dichloride was very active against mouse sarcoma and mouse leukemia. These researchers determined that cis-platinum II diamine dichloride is stabilized in aqueous solution in the presence of chloride ions.
In particular, boiling salt solutions with 30 sodium chloride concentrations stabilize from 0. Rossef et al. These researchers used a composition of freeze-dried active substance provided by the National Cancer Institute and.
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Ben Affleck and Ana de Armas Spotted in Her Native Cuba After Wrapping Thriller Together
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Weeks after Ben Affleck and Knives Out actress Ana de Armas wrapped their next movie together, the costars were seen having dinner in her native Cuba. The actors were spotted while out to eat and walking around Havana on Thursday, where de Armas is from. The two were pictured smiling and laughing on a walk around the Cuban capital by photographers and fans, who asked to take photos with the stars.
In one group picture , de Armas, 31, stands in front of Affleck, 47, as they smile while surrounded by fans. Another shot from a different outing, this time at restaurant La Corte del Principe, seems to show the two with a cook. The sightings come after the pair wrapped filming on Deep Water , a sexual thriller from Fatal Attraction director Adrian Lyne they shot on location in New Orleans over the winter.
Affleck and de Armas had been seen filming throughout the Louisiana city several times, including a day out on a field in November. The film is set to be released November It seems the two also spent some time together off set while filming as a fan in New Orleans tweeted about spotting them at a bar together in January. Affleck is fluent in Spanish and recently conducted several interviews for his new movie The Way Back in the language.
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